Matrixyl 3000 is a peptide formulation by Sederma, a Paris-based cosmetics ingredient manufacturer. The proprietary product is a combination ofpalmitoyl tripeptide-1 and palmitoyl tripeptide-7, both of which work together to boost skin quality and collagen production.
Matrixyl 3000’s primary benefit is its ability to reduce wrinkles and improve skin texture. Users often report their complexions look plumper and more hydrated after several weeks of use. Furthermore, most skin types tolerate the product well, which is why so many brands use it in their formulations.
However, is Matrixyl 3000 the only option? No. It turns out that there are numerous alternatives that also yield similar, if not better, results.
GHK-Cu (Copper Peptide)
Top of the list of alternatives is GHK-Cu copper peptide, used in Regen Labs’sLiquid Facelift. It delivers copper ions into the skin, improving collagen, elastin, and integrin production, often beating out other skin formulations in controlled trials (including retinoids and vitamin C).
GHK-Cu’s primary activity is collagen production and accelerated wound healing. The compound reduces skin inflammation, increases density and thickness, and boosts elasticity, helping to reduce laxity from sun damage.
Sometimes, formulations add GHK-Cu to target problem areas, including under-eye areas. That’s because the compound can penetrate through the skin and target fibroblasts in the deeper layers, encouraging them to stabilize and thicken the dermis. Other formulations apply to the entire face.
Niacinamide (Vitamin B3)
Simple niacinamide is another Matrixyl 3000 dupe included in our Liquid Facelift formulation. This form of vitamin B3 has a long history of improving the skin and addressing common complaints like laxity and wrinkles.
Niacinamide works by enhancing the skin defensive barrier. The essential nutrient interacts with tired surface and subsurface cells, inducing them to behave more youthfully and reducing hyperpigmentation and other aging signs.
As such, niacinamide is a common ingredient in premium moisturizers. However, you can also find it in dedicated face creams, usually as a side ingredient.
Tetrahexyldecyl Ascorbate (Vitamin C Ester)
Vitamin C ester might be less effective than GHK-Cu in head-to-head trials, but it is still a potent ingredient and Matrixyl 3000 alternative. The esterified version gets into the skin more effectively than conventional vitamin C, making it a favorite among seasoned beauty experts.
Vitamin C’s primary benefit is its skin-brightening effect. It offers potent antioxidant protection, preventing free radicals from oxidizing compounds in skin cells and causing damage.
Furthermore, it ismore comfortable than conventional ascorbic acid-containing products. Its special chemical configuration means it doesn’t irritate the skin as much.
Sodium Hyaluronate
Sodium hyaluronate isn’t a direct substitute for Matrixyl 3000 but it is an excellent skin-plumper and works well with other dupes, like GHK-Cu. As a humectant (a moisturizer), it helps keep water in the skin, making it bouncier and more hydrated while concealing fine lines.
Acetyl Hexapeptide-8 (Argireline)
Argireline is another peptide that acts similarly to Matrixyl 3000. It works like injectables by reducing muscle movements, cutting down on the formation of lines and wrinkles.
Most women apply argireline-containing products to the brow, forehead, and eye area. However, it is safe to use in any area experiencing unwanted wrinkles and fine lines.
Many people like argireline because it is less invasive than injectables. You rub it into the skin instead of getting a long series of injections.
Palmitoyl Tripeptide-5
Palmitoyl tripeptide-5 is another Matrixyl 3000 dupe in our Liquid Facelift formulation. That’s because it also promotes collagen production and reduces the signs of fine lines and wrinkles.
Interestingly, some users may be more responsive to palmitoyl tripeptide-5 than others. As such, adding it complements the existing peptides in the formulation, and may make the product more universally effective.
Panthenol
Panthenol is a form of vitamin B5 that complements existing peptides in formulations, including in Liquid Facelift. It improves skin barrier function and helps the upper dermal layers remain hydrated, similar to hyaluronic acid.
Syn-Ake (Dipeptide Diaminobutyroyl Benzylamide Diacetate)
Syn-ake is also true Matrixyl 3000 dupe and another ingredient that can claim to be injectables in a bottle. The compound is made from snake venom and, like botulism toxin, reduces facial muscle contractions to prevent the formation of fine lines and wrinkles.
Syn-ake is most effective around more active parts of the face, like the eyes and mouth. The ingredient reduces movement in these regions, making lines appear less noticeable over time.
Dupes For Matrixyl 3000
In summary, today’s market offers numerous alternatives to Matrixyl 3000. However, many products use a selection of peptides as a combination is often more effective for a broader array of skin types.