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Brain Health Benefits of the Vitamin B1 Derivative, Bisibuthiamine

Kind-bearded-man-wearing-official-costume | feature | Brain Health Benefits of the Vitamin B1 Derivative, Sulbutiamine

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Bisibuthiamine – developed in Japan in the 1960’s – may provide a solution to thiamine (vitamin B1) deficiency, which affects brain health.

RELATED: How To Effectively Get Rid Of Brain Fog


1. The Importance of Vitamin B1

Vitamin B1 (thiamine) is vital to brain functions like memory, attention span, responsiveness to environmental stimuli, moodiness and depression. When B1 levels drop too low, brain health declines, resulting in reduced functionality and quality of life. Chronically low B1 can even lead to fatal brain illnesses like Wernicke’s encephalopathy.

Thiamine-dependent enzymes are crucial to the metabolism of glucose, the brain’s only source of food. Abundant studies have shown that thiamine deficiency is associated with neurological problems like cognitive deficits, memory failure, and serious diseases like encephalopathy and Alzheimer’s. In pre-clinical models, reduced thiamine has driven Alzheimer’s-like abnormalities including memory deficits, plaque, and hyperphosphorylation.


2. What is Bisibuthiamine?

Since the 60’s when it was first developed in Japan, research into bisibuthiamine – a thiamine derivative – has spread from its origin in Japan throughout the world. So, what is this 60-year-old supplement, bisibuthiamine?

Bisibuthiamine is simply two thiamine (vitamin B1) molecules fused together with a disulfide bridge. It is a man-made supplement similar to vitamin B1 that may fulfill many of the same functions. It is a mild stimulant that has been reported to improve recognition, memory, reasoning, and attention.


3. Benefits of Bisibuthiamine & How it Works

Brain Health Benefits of the Vitamin B1 Derivative, Bisibuthiamine

There is insufficient research into why bisibuthiamine works. But users report better strength in addition to improved brain functions. Participants in medical reviews have stated that their memory and mood both improved after taking Bisibuthiamine regularly.

More research is needed into how bisibuthiamine works, but studies have shown that bisibuthiamine increases levels of thiamine and thiamine phosphates in the brain, thereby having the potential to affect asthenia (weakness) and chronic fatigue.

The treatment has also been measured in studies to improve memory function in lab tests on animals. And a recent research review found that Bisibuthiamine is also thought to have neuroprotective effects due mainly to its thiol content, which can affect antioxidant content.

And in one of the few studies on human participants, a randomized, double-blind study of early-stage Alzheimer’s patients, Bisibuthiamine (taken with donepezil, a cholinesterase inhibitor) improved episodic memory, attention, and normal activities compared with taking the donepezil alone.


If you have questions about Bisibuthiamine or brain health, Regen Labs has options for you. All Regen Labs products support the body’s natural systems for healthy brain, skin, muscle, and sexual health.

Without toxins or synthetic chemicals, Regen Labs products contain research-proven ingredients to boost the body’s natural ability to be healthy.

Let’s talk! If you have questions, we would love to connect. Reach us at [email protected].


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